Abstract Klopp, Harms
We present results of a placebo-controlled double-blind study to improve the functional state of microcirculation in patients with type 2 diabetes. The following three different therapeutic options were applied for 30 days and compared with respect to their impact on the reduced functional state of microcirculation in these patients:
(1) Placebo=daily exercise on a treadmill for 60 min under normoxic conditions without physical vascular therapy,
(2) Verum 1=daily exercise on a treadmill for 60 min under hyperoxic conditions (oxigen content 26 vol%) without physical vascular therapy,
(3) Verum 2= daily exercise on a treadmill for 60 min under hyperoxic conditions (oxigen content 26 vol%) with physical vascular therapy/BEMER classic.
The functional state of microcirculation was assessed by means of high-resolution measurements using an intravital-microscopic unit of investigation, reflexion spectrometry and Laser-DOPPLER microfluidic measurements. The patients treated with Verum 2 revealed the best therapeutic results. In this group the oxygen utilisation in the target tissue was increased by 40%, the distribution of blood in capillary networks was improved by 30% and the venular flow condition showed an increase of 50%. These differences were statistically significant. Therefore the treatment including a physical vascular therapy with BEMER classic proved to be the most efficient therapy.